MST2

MST2 (STK3) is a core Hippo pathway kinase that regulates organ size, self-renewal, tissue homeostasis, apoptosis, and tumor suppression through MST1/2-LATS1/2 control of YAP/TAZ activity^[1]^[2]. Mechanistically, MST2 participates in MST1/2-dependent phosphorylation signaling to MOB1, LATS1/2, and YAP, linking cell contact, substrate stiffness, growth control, and stress-associated apoptosis^[1]^[3]. In cancer models, MST2 contributes to apoptosis machinery in HER2⁺ breast cancer cells, while STK3 activation inhibits ESCC proliferation and migration through FOXO1-TP53INP1/P21 signaling^[3]^[4]. Compared with related isoforms, MST2 differs functionally from MST1 because MST2 was essential for MST1/N activation and apoptosis induction, and differs from MST3 because MST3 regulates AMPK and YAP-Hippo signaling in renal fibrosis models^[3]^[5]. For experimental applications, XMU-MP-1 is a reversible MST1/2 inhibitor that blocks MST1/2 kinase activity, activates YAP, and promotes liver and intestinal repair in acute and chronic injury models^[6].

References:

[1]. Passi M, et al. CDK5 interacts with MST2 and modulates the Hippo signalling pathway. FEBS Open Bio. 2025 Apr;15(4):647-660. [Content Brief]

[2]. Cinar B, et al. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007 Oct 31;26(21):4523-34. [Content Brief]

[3]. Turunen SP, et al. FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ. 2019 Dec;26(12):2577-2593. [Content Brief]

[4]. Zhao Z, et al. STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma. Cell Oncol (Dordr). 2024 Aug;47(4):1295-1314. [Content Brief]

[5]. Chan CH, et al. MST3 Regulates AMPK and YAP-Hippo Signaling in Cell Models Relevant to Renal Fibrosis. Biomol Ther (Seoul). 2025 Jul 1;33(4):704-715. [Content Brief]

[6]. Fan F, et al. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med. 2016 Aug 17;8(352):352ra108. [Content Brief]

MST2 Related Products (3):

By Type:	Selective (1)
By Effects:	Inhibitors (2) Activator (1)

Cat. No.	Product Name	Effect	Purity

HY-132969

SBP-3264	Inhibitor	98.50%
SBP-3264 is a YAP activator and STK/MST inhibitor with IC₅₀ values of 36 nM against STK3/MST2 and 24 nM against STK4/MST1. SBP-3264 modulates the Hippo signaling pathway. SBP-3264 can be used for the research of acute myeloid leukemia.

HY-164595

IHMT-MST1-39	Inhibitor	99.68%
IHMT-MST1-39 is an orally active inhibitor for MST kinase, with IC₅₀ of 42, 109, 286, 159 nM for MST1, MST2, MST3, MST4. IHMT-MST1-39 activates the AMPK signaling pathway in liver cells, reduces apoptosis of pancreatic β-cells. IHMT-MST1-39 can be used for the studies of type 1 diabetes (T1D) and type 2 diabetes (T2D).

HY-186148

YL-602	Activator
YL-602 is an orally active Hippo pathway activator. YL-602 activates the Hippo pathway via MST1/2, with downstream pathway activation. YL-602 inhibits YAP and CTGF expression in cells irrespective of cell density and serum presence. YL-602 induces tumor cell apoptosis and inhibits colony formation. YL-602 suppresses tumor growth in mice. YL-602 can be used for the research of cancer, such as breast cancer.

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